肾小管上皮细胞间充质转分化的调控机制及中药的干预作用(7)
Nanjing University Medical School， Nanjing 210008， China)[Abstract]Epithelial to mesenchymal transition(EMT)has been proposed as a key role leading to the progressive tubulo-interstitial fibrosis(TIF). The tubular EMT is an highly regulated process involving four key steps including：loss of epithelial cell adhesion，de novo smooth muscle actin expression and actin reorganization，disruption of tubular basement membrane，and enhanced cell migration and invasion. These crucial processes are closely connected to the relative actions on many signaling pathways in EMT. Additionally，increasing evidences suggest that some Chinese herbal medicines and their extracts，such as Astragali Radix，Cordyceps，Salvia miltiorrhiza，as well as Chinese herbal prescriptions including Astragalus Angelica mixture and Supplementing Qi and activating blood circulation decoction，could intervene the related events controlling EMT both in vitro and in vivo. Chinese herbal medicines could ameliorate TIF by intervening the course of EMT.
[Key words]chronic kidney disease； tubulo-interstitial fibrosis； epithelial to mesenchymal transition； Chinese herbal medicine
doi：10.4268/cjcmm20130505[责任编辑张宁宁], http://www.100md.com(尹雪皎 孙伟 万毅刚 涂玥 刘红 於丙寅)
[Key words]chronic kidney disease； tubulo-interstitial fibrosis； epithelial to mesenchymal transition； Chinese herbal medicine
doi：10.4268/cjcmm20130505[责任编辑张宁宁], http://www.100md.com(尹雪皎 孙伟 万毅刚 涂玥 刘红 於丙寅)