八仙花叶化学成分研究(6)
Heilongjiang Key Laboratory of Traditional Chinese Medicine Pharmacodynamic Material Bases， Harbin 150040， China；
2. School of Pharmacy， Harbin Medical University， Harbin 150081， China)
[Abstract]Objective： To investigate chemical constituents from Chinese herbal medicine Hydrangea macrophylla. Method： The compounds were separated and purified by column chromatography over silica gel， ODS， and preparative HPLC. Their structures were identified by spectral methods including 1H， 13C-NMR and MS. Result： Eleven compounds were isolated and identified as zeorin， hopane-6， 22-diol (1)， botulin (2)， betulinic acid (3)， 2-ethyl-3-methyl-maleimide-N-β-D-glucopyranoside (4)， uridine (5)， thymidine (6)， adenosine (7)， nicotinamide (8)， methyl pyroglutamate (9)， hydrangenol (10) and hydrangenol-4′-O-β-D-glucopyranoside(11)， respectively. Conclusion： Compounds 1-4 and 7-9 were obtained from the genus Hydrangea for the first time.
[Key words]Saxifragaceae； Hydrangea macrophylla； triterpenoid； nitrogenous compounds； isocoumarin
doi：10.4268/cjcmm20130519
[责任编辑孔晶晶], http://www.100md.com(王知斌 郭江涛 杨春娟 孟永海 王秋红 杨炳友 匡海学)
2. School of Pharmacy， Harbin Medical University， Harbin 150081， China)
[Abstract]Objective： To investigate chemical constituents from Chinese herbal medicine Hydrangea macrophylla. Method： The compounds were separated and purified by column chromatography over silica gel， ODS， and preparative HPLC. Their structures were identified by spectral methods including 1H， 13C-NMR and MS. Result： Eleven compounds were isolated and identified as zeorin， hopane-6， 22-diol (1)， botulin (2)， betulinic acid (3)， 2-ethyl-3-methyl-maleimide-N-β-D-glucopyranoside (4)， uridine (5)， thymidine (6)， adenosine (7)， nicotinamide (8)， methyl pyroglutamate (9)， hydrangenol (10) and hydrangenol-4′-O-β-D-glucopyranoside(11)， respectively. Conclusion： Compounds 1-4 and 7-9 were obtained from the genus Hydrangea for the first time.
[Key words]Saxifragaceae； Hydrangea macrophylla； triterpenoid； nitrogenous compounds； isocoumarin
doi：10.4268/cjcmm20130519
[责任编辑孔晶晶], http://www.100md.com(王知斌 郭江涛 杨春娟 孟永海 王秋红 杨炳友 匡海学)