中药注射液对自体脂肪颗粒移植存活率的影响(1)
[摘要]目的：探索对兔自体脂肪颗粒移植存活率有促进作用的中药注射液。方法：20只兔建立自体脂肪颗粒移植模型，随机分为5组，各组分别肌肉注射生脉、刺五加、黄芪、参麦注射液及生理盐水0.37ml/kg·d，90d后检测移植脂肪的质量，计算移植脂肪存活率。结果：术后90d，4种中药组移植存活率均高于对照组，差异均有统计学意义(P<0.05)，生脉组移植成活率较高(P<0.05)。4种中药组血清VEGF表达水平在移植术后1周、3周和6周均明显高于对照组，生脉组显著高于其它3组，差异有统计学意义(P<0.05)；4种中药组毛细血管密度均较对照组明显增高，生脉组高于其它3组，差异有统计学意义(P<0.05)。结论：0.37ml/kg·d剂量时，4种中药都可提高自体脂肪颗粒移植存活率，但是生脉的作用最强。
[关键词]中药；生脉注射液；黄芪注射液；参麦注射液；刺五加注射液；自体脂肪移植；存活率
[中图分类号]R622+.9 [文献标志码]A [文章编号]1008-6455(2018)05-0115-03
, 百拇医药
Effects of Traditional Chinese Medicine Injection on the Survival Rate of
Autologous Fat Grafting
LIN Hui，WANG Lin-na，WEN Qing，LIANG Gui-zhi
(Department of Laser and Plastic Surgery，the First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530022，Guangxi，China)
Abstract： Objective To explore the traditional chinese medicine to promote the survival rate of autologous fat grafting in rabbits. Methods Twenty rabbits were randomly divided into five groups. The groups were given different doses of shengmai， ciwujia， huangqi， shenmai and normal saline by intramuscular injection. Ninety days later， the survival weight of the fat grafts were detected and the survival rates were calculated. Results The survival rates of the four Chinese medicine groups were higher than that of the control group after 90d， the differences were statistically significant(P<0.05). The survival rate of the grafts in the Shengmai group was higher than that of the other three groups(P<0.05). The level of serum VEGF in the four Chinese medicine groups were significantly higher than that of the control group at 1 week， 3 weeks and 6 weeks after transplantation， and the Shengmai group was significantly higher than that of the other three groups(P<0.05). The capillary density of the four Chinese medicine groups were significantly higher than that of the control group， and the Shengmai group was higher than the other three groups(P<0.05). Conclusion The survival rate of autologous fat grafting was improved by the four kinds of chinese medicine， but the effect of shengmai injection was the strongest at this dose of 0.37ml/kg·d.
, 百拇医药
Key words： traditional chinese medicine； shengmai injection； huangqi injection； shenmai injection； ciwujia injection； autologous fat grafting； survival rate
自體脂肪组织作为理想的软组织填充物，具有取材容易、无免疫排斥等优点。但注射脂肪存在着吸收率较高的问题，严重影响了自体脂肪移植效果[1-2]。生脉、刺五加、黄芪、参麦均具有活血化淤，改善微循环、保护细胞等功效。为了探讨中药对脂肪移植成活率的影响，本实验研究肌肉注射这4种中药对兔自体脂肪颗粒移植成活率的影响。现报道如下。
1 材料和方法, http://www.100md.com(林辉 王琳娜 文清 梁桂枝)
[关键词]中药；生脉注射液；黄芪注射液；参麦注射液；刺五加注射液；自体脂肪移植；存活率
[中图分类号]R622+.9 [文献标志码]A [文章编号]1008-6455(2018)05-0115-03
, 百拇医药
Effects of Traditional Chinese Medicine Injection on the Survival Rate of
Autologous Fat Grafting
LIN Hui，WANG Lin-na，WEN Qing，LIANG Gui-zhi
(Department of Laser and Plastic Surgery，the First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530022，Guangxi，China)
Abstract： Objective To explore the traditional chinese medicine to promote the survival rate of autologous fat grafting in rabbits. Methods Twenty rabbits were randomly divided into five groups. The groups were given different doses of shengmai， ciwujia， huangqi， shenmai and normal saline by intramuscular injection. Ninety days later， the survival weight of the fat grafts were detected and the survival rates were calculated. Results The survival rates of the four Chinese medicine groups were higher than that of the control group after 90d， the differences were statistically significant(P<0.05). The survival rate of the grafts in the Shengmai group was higher than that of the other three groups(P<0.05). The level of serum VEGF in the four Chinese medicine groups were significantly higher than that of the control group at 1 week， 3 weeks and 6 weeks after transplantation， and the Shengmai group was significantly higher than that of the other three groups(P<0.05). The capillary density of the four Chinese medicine groups were significantly higher than that of the control group， and the Shengmai group was higher than the other three groups(P<0.05). Conclusion The survival rate of autologous fat grafting was improved by the four kinds of chinese medicine， but the effect of shengmai injection was the strongest at this dose of 0.37ml/kg·d.
, 百拇医药
Key words： traditional chinese medicine； shengmai injection； huangqi injection； shenmai injection； ciwujia injection； autologous fat grafting； survival rate
自體脂肪组织作为理想的软组织填充物，具有取材容易、无免疫排斥等优点。但注射脂肪存在着吸收率较高的问题，严重影响了自体脂肪移植效果[1-2]。生脉、刺五加、黄芪、参麦均具有活血化淤，改善微循环、保护细胞等功效。为了探讨中药对脂肪移植成活率的影响，本实验研究肌肉注射这4种中药对兔自体脂肪颗粒移植成活率的影响。现报道如下。
1 材料和方法, http://www.100md.com(林辉 王琳娜 文清 梁桂枝)