加味柴芍六君汤联合调神针刺法治疗肝脾不和型慢性浅表性胃炎的临床效果(1)
摘要 目的：探讨肝脾不和型慢性浅表性胃炎(CSG)经加味柴芍六君汤联合调神针刺法辅助治疗后的临床效果。方法：选取2015年7月至2018年9月西安交通大学第一附属医院收治的CSG患者139例作为研究对象，按照随机数字表法分为对照组(n=69)和观察组(n=70)。对照组采用常规西医治疗，观察组采用常规西医治疗+加味柴芍六君汤联合调神针刺法治疗，比较2组患者临床疗效、相关CSG积分、胃肠激素及焦虑抑郁状况，同时观察2组不良反应发生情况。结果：观察组治疗后治疗有效率高于对照组，差异有统计学意义(P<0.05)。观察组治疗4周后胃镜检查积分反酸、嗳气、上腹胀，差异有统计学意义(P<0.05)。观察组治疗4周后生长抑素(SS)、胃动力素(MTL)高于对照组，差异有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论：加味柴芍六君汤联合调神针刺法辅助治疗肝脾不和型CSG患者，疗效确切，可有效缓解临床症状，改善胃肠激素指标及焦虑抑郁情绪，且安全性较好。
关键词 肝脾不和;调神针刺法;焦虑抑郁;加味柴芍六君汤;疗效;胃肠激素;慢性浅表性胃炎;不良反应
Abstract Objective：To explore the curative effects of Jiawei Chaishao Liujun Decoction combined with Tiaoshen acupuncture on chronic superficial gastritis(CSG)of liver-spleen disharmony.Methods：A total of 139 CSG patients were selected from July 2015 to September 2018 in the First Affiliated Hospital of Xi′an Jiaotong University and were divided into a control group(n=69，routine Western medicine)and a study group(n=70，conventional Western medicine plus modified Chaishao Liujun Decoction combined with Tiaoshen acupuncture)according to random number table method.The clinical efficacy，relevant CSG score，gastrointestinal hormones and anxiety and depression were compared between the 2 groups，and adverse reactions during treatment were observed between the 2 groups.Results：The total effective rate in the study group was higher than that in the control group(P<0.05).After 4 weeks of treatment，gastroscopy scores of acid reflux，belching，upper abdominal distention，anorexia，epigastric pain，gastrin(GAS)，self-rating anxiety scale(SAS)and self-rating depression scale(SDS)in the study group were lower than those in the control group(P<0.05).After 4 weeks of treatment，the levels of somatostatin(SS)and motilin(MTL)in the study group were higher than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion：Jiawei Chaishao Liujun Decoction combined with Tiaoshen acupuncture has definite curative effects on CSG patients with of liver-spleen disharmony.It can effectively relieve clinical symptoms，improve gastrointestinal hormone indexes and anxiety and depression，with good safety.
Keywords Liver and spleen disharmony; Tiaoshen acupuncture; Anxiety and depression; Modified Chaishao Liujun Decoction; Therapeutic effects; Gastrointestinal hormone; Chronic superficial gastritis; Adverse reactions
中圖分类号：R242;R289.5文献标识码：Adoi：10.3969/j.issn.1673-7202.2020.19.026, http://www.100md.com(张玉磊 高路 王艳丽 苗金钰 杨薪博)
关键词 肝脾不和;调神针刺法;焦虑抑郁;加味柴芍六君汤;疗效;胃肠激素;慢性浅表性胃炎;不良反应
Abstract Objective：To explore the curative effects of Jiawei Chaishao Liujun Decoction combined with Tiaoshen acupuncture on chronic superficial gastritis(CSG)of liver-spleen disharmony.Methods：A total of 139 CSG patients were selected from July 2015 to September 2018 in the First Affiliated Hospital of Xi′an Jiaotong University and were divided into a control group(n=69，routine Western medicine)and a study group(n=70，conventional Western medicine plus modified Chaishao Liujun Decoction combined with Tiaoshen acupuncture)according to random number table method.The clinical efficacy，relevant CSG score，gastrointestinal hormones and anxiety and depression were compared between the 2 groups，and adverse reactions during treatment were observed between the 2 groups.Results：The total effective rate in the study group was higher than that in the control group(P<0.05).After 4 weeks of treatment，gastroscopy scores of acid reflux，belching，upper abdominal distention，anorexia，epigastric pain，gastrin(GAS)，self-rating anxiety scale(SAS)and self-rating depression scale(SDS)in the study group were lower than those in the control group(P<0.05).After 4 weeks of treatment，the levels of somatostatin(SS)and motilin(MTL)in the study group were higher than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the 2 groups(P>0.05).Conclusion：Jiawei Chaishao Liujun Decoction combined with Tiaoshen acupuncture has definite curative effects on CSG patients with of liver-spleen disharmony.It can effectively relieve clinical symptoms，improve gastrointestinal hormone indexes and anxiety and depression，with good safety.
Keywords Liver and spleen disharmony; Tiaoshen acupuncture; Anxiety and depression; Modified Chaishao Liujun Decoction; Therapeutic effects; Gastrointestinal hormone; Chronic superficial gastritis; Adverse reactions
中圖分类号：R242;R289.5文献标识码：Adoi：10.3969/j.issn.1673-7202.2020.19.026, http://www.100md.com(张玉磊 高路 王艳丽 苗金钰 杨薪博)